Kitson Sean L
GE Healthcare Limited, Amersham Place, Little Chalfont, Buckinghamshire, HP7 9NA, UK.
Curr Pharm Des. 2007;13(25):2621-37. doi: 10.2174/138161207781663000.
Serotonin (5-HT) receptors are part of the G protein-coupled and ligand-gated ion channel families. 5-HT exerts its diverse actions by binding to cell surface receptors which can be classified into seven distinct families (5-HT1 to 5-HT7) according to their structural diversity and mode of action. Some of the 5-HT families are comprised of multiple receptors which share similar structural and mechanistic properties but display very different operational profiles. Evidence continues to mount in support of the important roles of the 5-HT receptors in various neuropsychiatric disorders such as anxiety, depression, schizophrenia, migraine and drug addiction. The 5-HT receptors may also play an important role in obesity, aggression, sexual behaviour and cardiovascular disorders. A number of selective/non-selective 5-HT agonist and antagonist ligands (drugs) have been developed to challenge many of these disease states.
血清素（5-羟色胺，5-HT）受体属于G蛋白偶联受体家族和配体门控离子通道家族。5-HT通过与细胞表面受体结合发挥其多样的作用，这些受体根据其结构多样性和作用方式可分为七个不同的家族（5-HT1至5-HT7）。5-HT家族中的一些家族由多个受体组成，这些受体具有相似的结构和机制特性，但表现出非常不同的功能特征。越来越多的证据支持5-HT受体在各种神经精神疾病（如焦虑症、抑郁症、精神分裂症、偏头痛和药物成瘾）中发挥重要作用。5-HT受体在肥胖、攻击行为、性行为和心血管疾病中也可能起重要作用。已经开发出许多选择性/非选择性5-HT激动剂和拮抗剂配体（药物）来应对许多这些疾病状态。
