Meda N, Traore G S, Meda H A, Curtis V, Cousens S N, Mertens T E
Maternité Hôpital National Sourô Sanon, Bobo-Dioulasso, Burkina Faso.
Ann Soc Belg Med Trop. 1991 Dec;71(4):307-16.
A total of 96 mothers of stillborn babies (cases) and 402 mothers of live-born babies (controls) were studied between the 1st November 1988 and the 31st July 1989 in an attempt to identify the risk factors for the high number of stillbirths in the Maternity wing of the Hôpital National Sourô SANON in Bobo-Dioulasso, Burkina Faso. From a stratified analysis, eight risk factors emerged as significant predictors of mortality: mother older than 35 years, high parity (five or more), previous history of stillbirth, lack of medical supervision of pregnancy, interval between last consultation and birth longer than 30 days, complications during delivery and birth weight less than 2,500 g. Polygamy was associated with a 51% reduction in the risk of stillbirth. The problem of selection bias which affects the validity of hospital based case-control studies is discussed. Techniques for reducing selection bias in hospital based case-control studies are proposed. Improvements in antenatal care in Bobo-Dioulasso are suggested.
1988年11月1日至1989年7月31日期间，对布基纳法索博博迪乌拉索市索罗·萨农国家医院产科病房中96名死产婴儿的母亲（病例组）和402名活产婴儿的母亲（对照组）进行了研究，旨在确定导致死产率高的危险因素。通过分层分析，确定了八个危险因素为死亡率的显著预测因素：母亲年龄超过35岁、多胎（五胎及以上）、有死产史、孕期缺乏医疗监护、上次产检与分娩间隔超过30天、分娩并发症以及出生体重低于2500克。一夫多妻制与死产风险降低51%相关。讨论了影响基于医院的病例对照研究有效性的选择偏倚问题。提出了减少基于医院的病例对照研究中选择偏倚的技术。建议改善博博迪乌拉索的产前护理。
