Mangone C A, Hier D B, Gorelick P B, Ganellen R J, Langenberg P, Boarman R, Dollear W C
Center for Alzheimer Disease, Humana Hospital-Michael Reese, Chicago, IL.
J Geriatr Psychiatry Neurol. 1991 Oct-Dec;4(4):189-93. doi: 10.1177/089198879100400402.
We studied insight into illness in 41 patients with probable Alzheimer's disease. An impaired insight score was developed by measuring discrepancies between patient report and caregiver report on standard instruments of activities of daily living. Insight was more impaired in subjects with greater dementia severity and subjects with paranoid delusions. In a multivariate analysis, the best neuropsychological predictors of impaired insight were the Continuous Performance Test and the Visual Reproduction Test. We speculate that the impaired insight of Alzheimer's disease has two components: confabulation reflecting prefrontal dysfunction and anosognosia reflecting right-hemisphere dysfunction.
我们对41例可能患有阿尔茨海默病的患者的疾病洞察力进行了研究。通过测量患者报告与照料者报告在日常生活活动标准工具上的差异，得出了洞察力受损评分。痴呆严重程度较高的受试者和患有偏执妄想的受试者的洞察力受损更严重。在多变量分析中，洞察力受损的最佳神经心理学预测指标是连续操作测试和视觉再现测试。我们推测，阿尔茨海默病患者的洞察力受损有两个组成部分：反映前额叶功能障碍的虚构和反映右半球功能障碍的疾病感缺失。
