人脑水共振周围磁化传递效应不对称性的定量描述。
Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain.
作者信息
Hua Jun, Jones Craig K, Blakeley Jaishri, Smith Seth A, van Zijl Peter C M, Zhou Jinyuan
机构信息
Department of Radiology, Division of MRI Research, Neurosection, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2109, USA.
出版信息
Magn Reson Med. 2007 Oct;58(4):786-93. doi: 10.1002/mrm.21387.
Abstract
Magnetization transfer (MT) imaging provides a unique method of tissue characterization by capitalizing on the interaction between solid-like tissue components and bulk water. We used a continuous-wave (CW) MT pulse sequence with low irradiation power to study healthy human brains in vivo at 3 T and quantified the asymmetry of the MT effects with respect to the water proton frequency. This asymmetry was found to be a difference of approximately a few percent from the water signal intensity, depending on both the RF irradiation power and the frequency offset. The experimental results could be quantitatively described by a modified two-pool MT model extended with a shift contribution for the semisolid pool with respect to water. For white matter, this shift was fitted to be 2.34 +/- 0.17 ppm (N = 5) upfield from the water signal.
摘要
磁化传递（MT）成像利用类固体组织成分与大量水之间的相互作用，提供了一种独特的组织表征方法。我们使用具有低辐照功率的连续波（CW）MT脉冲序列，在3T磁场下对健康人体大脑进行活体研究，并量化了MT效应相对于水质子频率的不对称性。发现这种不对称性与水信号强度相差约百分之几，这取决于射频辐照功率和频率偏移。实验结果可以通过一个修正的双池MT模型进行定量描述，该模型扩展了半固体池相对于水的位移贡献。对于白质，该位移拟合为相对于水信号在其高场方向2.34±0.17 ppm（N = 5）处。
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