Kolpakov V G, Barykina N N, Alekhina T A, Chepkasov I L
Institute of Cytology and Genetics, Novosibirsk, USSR.
Behav Processes. 1985 Jan;10(1-2):63-76. doi: 10.1016/0376-6357(85)90118-4.
Outbred Wistar rats were selectively bred for predisposition to catalepsy for 16 generations. The rats predisposed to catalepsy are characterized by an increased (in an unselected control population) or decreased (in S13) motor activity, decreased defecation scores, and elevated blood pressure. Selective breeding for catalepsy for 16 generations resulted in the production of a stock with about 50% of the animals showing a consistent cataleptic reaction, versus about 10% in the control unselected stock. From segregation analysis it was concluded that predisposition to catalepsy is inherited as an oligogenic dominant characteristic with incomplete penetrance. The same seems to be the case with predisposition to pendulum movements. There is a positive phenotypical and genetic relationship between predisposition to catalepsy and predisposition to pendulum movements, and a negative relationship between predisposition to catalepsy and incidence of audiogenic seizures. A genetic model for the relationship between catalepsy, pendulum movements and audiogenic epilepsy is proposed.
远交系Wistar大鼠被选择性培育出对僵住症有易感性的品系，持续了16代。易患僵住症的大鼠的特征是（与未选择的对照群体相比）运动活动增加（在S13中则减少）、排便评分降低以及血压升高。对僵住症进行16代的选择性培育导致产生了一个品系，其中约50%的动物表现出持续的僵住反应，而对照未选择的品系中这一比例约为10%。通过分离分析得出结论，对僵住症的易感性作为一种具有不完全外显率的寡基因显性特征遗传。对摆动运动的易感性似乎也是如此。僵住症易感性和摆动运动易感性之间存在正的表型和遗传关系，而僵住症易感性与听源性惊厥的发生率之间存在负相关。提出了一个关于僵住症、摆动运动和听源性癫痫之间关系的遗传模型。
