Karbakhsh Mojgan, Zandi Negar Salehian
Sina Trauma Research Center, Medical Sciences/University of Tehran, Tehran, Iran.
Clin Toxicol (Phila). 2008 Mar;46(3):211-7. doi: 10.1080/15563650701638982.
Poisoning is considered a significant health problem in the elderly. This study aimed to portray the pattern of poisoning in the elderly population of Tehran.
This cross-sectional study included all patients aged 60 years and older with acute poisoning who attended the emergency department of the Loghman-Hakim hospital over a six-month period (n=299).
Episodes of poisoning were more common in men (70.9%) and the majority of incidents took place in the patient's own home (84.3%). Most episodes were accidental (53.2%) followed by attempted suicide (32.4%). Opioids and opiate products accounted for 54.02% of the non-pharmaceutical substances that were involved in episodes of poisoning. Overdose with opioids and opiate products, was higher in male patients than in female patients. The most frequently involved drug groups were benzodiazepines, antidepressants, and analgesics. The most common cause of accidental poisoning was overdose by drug abusers. The Poisoning Severity Score was minor in 25.4%, moderate in 52.2%, and severe in 17.1% of patients. Asymptomatic patients accounted for 5.4% of the total. Unfortunately, 11.7% of patients died. The main agents involved in the fatal cases were opioids and opiate products.
The commonest method of accidental poisoning was overdose in opioid and opiate abusers. Attempted suicide was also very common comprising about one third of all cases. The high mortality observed in this study warrants attention to the risk factors and prognostic factors of poisoning in elderly.
中毒被认为是老年人中一个重要的健康问题。本研究旨在描绘德黑兰老年人群中的中毒模式。
这项横断面研究纳入了所有60岁及以上因急性中毒到洛格曼 - 哈基姆医院急诊科就诊的患者(n = 299)。
中毒事件在男性中更为常见(70.9%),且大多数事件发生在患者自己家中(84.3%)。大多数中毒事件是意外(53.2%),其次是自杀未遂(32.4%)。阿片类药物和阿片制品占中毒事件所涉及非药物物质的54.02%。男性患者阿片类药物和阿片制品过量的情况高于女性患者。最常涉及的药物类别是苯二氮䓬类、抗抑郁药和镇痛药。意外中毒最常见的原因是药物滥用者过量用药。25.4%的患者中毒严重程度评分为轻度,52.2%为中度,17.1%为重度。无症状患者占总数的5.4%。不幸的是,11.7%的患者死亡。致命病例中涉及的主要药物是阿片类药物和阿片制品。
意外中毒最常见的方式是阿片类药物和阿片滥用者过量用药。自杀未遂也很常见,约占所有病例的三分之一。本研究中观察到的高死亡率值得关注老年人中毒的危险因素和预后因素。