Kotan Recep, Kordali Saban, Cakir Ahmet
Ataturk University, Biotechnology Research and Application Center, 25240-Erzurum, Turkey.
Z Naturforsch C J Biosci. 2007 Jul-Aug;62(7-8):507-13. doi: 10.1515/znc-2007-7-808.
Plant essential oils are widely used as fragrances and flavours in the cosmetic, perfume, drug and food industries. Oxygenated monoterpenes are widespread components of the essential oils, usually occurring in high amount. In this paper, the antibacterial activities of twenty-one oxygenated monoterpenes (borneol, borneol acetate, camphor, carvone, 1,8-cineole, citronellal, beta-citronellol, dihydrocarvone, fenchol, fenchone, geraniol acetate, isomenthol, limonene oxide, linalool, linalool acetate, nerol, nerol acetate, terpinen-4-ol, alpha-terpineol, menthol and menthone) and penicillin (standard antibiotic) were determined using a disc diffusion method (in vitro) against 63 bacterial strains, belonging to 37 different genera and 54 species (plant, food and clinic origins). The results showed that the oxygenated monoterpenes exhibited a variable degree of antibacterial activities. These compounds also inhibited the growth of bacterial strains by producing a weak zone of inhibition from 7 to 11 mm in diameter, depending on the susceptibility of the tested bacteria. Among the tested compounds, nerol, linalool alpha-terpineol, fenchol and terpinen-4-ol showed antibacterial activity at a broad spectrum. However, their antibacterial activities were lower than those of penicillin. In contrast to these compounds, camphor and 1,8-cineole exhibited no inhibition effects on the growth of all tested bacteria.
植物精油在化妆品、香水、药品和食品工业中被广泛用作香料和调味剂。氧化单萜是精油中广泛存在的成分，通常含量较高。本文采用纸片扩散法（体外）测定了21种氧化单萜（冰片、醋酸冰片酯、樟脑、香芹酮、1,8-桉叶素、香茅醛、β-香茅醇、二氢香芹酮、小茴香醇、小茴香酮、醋酸香叶酯、异薄荷醇、氧化柠檬烯、芳樟醇、醋酸芳樟酯、橙花醇、醋酸橙花酯、松油-4-醇、α-松油醇、薄荷醇和薄荷酮）和青霉素（标准抗生素）对63株细菌的抗菌活性，这些细菌属于37个不同属和54个种（来自植物、食品和临床来源）。结果表明，氧化单萜表现出不同程度的抗菌活性。这些化合物还通过产生直径为7至11毫米的微弱抑菌圈来抑制细菌菌株的生长，这取决于受试细菌的敏感性。在所测试的化合物中，橙花醇、芳樟醇、α-松油醇、小茴香醇和松油-4-醇表现出广谱抗菌活性。然而，它们的抗菌活性低于青霉素。与这些化合物相反，樟脑和1,8-桉叶素对所有受试细菌的生长均无抑制作用。
