Tzakou Olga, Mylonas Philippos, Vagias Constantinos, Petrakis Panos V
Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 157 71 Athens, Greece.
Z Naturforsch C J Biosci. 2007 Jul-Aug;62(7-8):597-602. doi: 10.1515/znc-2007-7-823.
The insecticidal activity of the endemic species Galium melanantherum was evaluated against Crematogaster scutellaris ants and Kalotermes flavicollis termites. Iridoid glucosides 1-7 were isolated for the first time as metabolites of the investigated plant, along with the coumarin scopolin. The main components of the extract were found to be the non-acetylated iridoids: geniposidic acid (1), 10-hydroxyloganin (2), deacetyldaphylloside (3), monotropein (4), deacetylasperulosidic acid (5) and scandoside (6), while asperulosidic acid (7) was present only in minute quantities. All isolated metabolites were identified on the basis of their spectral data. Laboratory bioassays revealed significant levels of toxicity for 1-4 against Kalotermes flavicollis termites and Crematogaster scutellaris ants.
评估了本地物种黑花拉拉藤对黄胸散白蚁和黄胸木白蚁的杀虫活性。首次从被研究植物中分离出环烯醚萜苷1 - 7以及香豆素东莨菪苷作为代谢产物。提取物的主要成分是未乙酰化的环烯醚萜：栀子苷（1）、10 - 羟基马钱苷（2）、去乙酰虎皮楠苷（3）、水晶兰苷（4）、去乙酰车叶草苷酸（5）和 scandoside（6），而车叶草苷酸（7）仅微量存在。所有分离出的代谢产物均根据其光谱数据进行了鉴定。实验室生物测定表明，化合物1 - 4对黄胸散白蚁和黄胸木白蚁具有显著的毒性水平。
