从白花蛇舌草中分离出的环烯醚萜苷可抑制低密度脂蛋白氧化。

Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation.

作者信息

Kim Dong-Hyun, Lee Hyo-Jung, Oh Young-Jun, Kim Min-Jung, Kim Sung-Hoon, Jeong Tae-Sook, Baek Nam-In

机构信息

Graduate School of Biotechnology, Kyung Hee University, Suwon, Korea.

出版信息

Arch Pharm Res. 2005 Oct;28(10):1156-60. doi: 10.1007/BF02972979.

DOI:10.1007/BF02972979

PMID:16276972

Abstract

An iridoid glycoside, oldenlandoside III (5) was isolated from the n-butanol fraction of methanol extracts of the aerial parts of Oldenlandia diffusa Roxb. along with six others previously characterized iridoid glycosides; geniposidic acid (1), scandoside (2), feretoside (3), 10-omicron-benzoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7). Compounds 1, 2, and 7 inhibited LDL-oxidation, and showed 63.3+/-2.0, 62.2+/-1.6, and 63.8+/-1.5% inhibition, respectively, at a concentration of 20 microg/mL.

摘要

从白花蛇舌草地上部分甲醇提取物的正丁醇部位分离得到一种环烯醚萜苷，即车叶草苷III（5），以及其他六种已鉴定的环烯醚萜苷；栀子苷（1）、梓醇（2）、去乙酰车叶草苷（3）、10 - O - 苯甲酰梓醇甲酯（4）、asperulosidic acid（6）和去乙酰asperulosidic acid（7）。化合物1、2和7抑制低密度脂蛋白氧化，在浓度为20μg/mL时，抑制率分别为63.3±2.0%、62.2±1.6%和63.8±1.5%。