Platta Harald W, Erdmann Ralf
Ruhr-Universität Bochum, Medizinische Fakultät, Institut für Physiologische Chemie, Abteilung für Systembiochemie, Universitätsstr. 150, D-44780 Bochum, Germany.
Trends Cell Biol. 2007 Oct;17(10):474-84. doi: 10.1016/j.tcb.2007.06.009.
Peroxisomes are a dynamic compartment in almost all eukaryotic cells and have diverse metabolic roles in response to environmental changes and cellular demands. The accompanying changes in enzyme content or abundance of peroxisomes are accomplished by dynamically operating membrane- and matrix-protein transport machineries. This review discusses recent progress in understanding peroxisomal proliferation and maintenance, insertion of peroxisomal membrane proteins, compartmentalization of peroxisomal matrix proteins and selective degradation of peroxisomes via pexophagy.
过氧化物酶体是几乎所有真核细胞中的一个动态区室,在响应环境变化和细胞需求方面具有多种代谢作用。过氧化物酶体中酶含量或丰度的相应变化是通过动态运行的膜蛋白和基质蛋白转运机制来实现的。本文综述了在理解过氧化物酶体增殖与维持、过氧化物酶体膜蛋白插入、过氧化物酶体基质蛋白区室化以及通过pexophagy对过氧化物酶体进行选择性降解等方面的最新进展。