Platta Harald W, Erdmann Ralf
Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr-Universität Bochum, D-44780 Bochum, Germany.
FEBS Lett. 2007 Jun 19;581(15):2811-9. doi: 10.1016/j.febslet.2007.04.001. Epub 2007 Apr 9.
Peroxisomes are unique organelles whose physiological functions vary depending on the cellular environment or metabolic and developmental state of the organism. These changes in enzyme content are accomplished by the dynamically operating membrane and matrix protein import machineries of peroxisomes that rely on the concerted function of at least 20 peroxins. The import of folded matrix proteins is mediated by cycling receptors that shuttle between the cytosol and peroxisomal lumen. Receptor release back to the cytosol represents the ATP-dependent step of peroxisomal matrix protein import, which consists of two energy-consuming reactions: receptor ubiquitination and dislocation.
过氧化物酶体是独特的细胞器，其生理功能会因细胞环境或生物体的代谢及发育状态而有所不同。酶含量的这些变化是通过过氧化物酶体动态运作的膜和基质蛋白导入机制实现的，该机制依赖于至少20种过氧化物酶蛋白的协同作用。折叠的基质蛋白的导入由在细胞质和过氧化物酶体腔之间穿梭循环的受体介导。受体释放回细胞质代表过氧化物酶体基质蛋白导入的ATP依赖步骤，这由两个耗能反应组成：受体泛素化和错位。
