Sommerfeld B
Dermatology Clinic, Danavägen 7B, SE-18131 Lidingö, Sweden.
Phytomedicine. 2007 Nov;14(11):711-5. doi: 10.1016/j.phymed.2007.09.015.
Tricutan is a combination product of herbal extracts traditionally used for treatment of skin conditions, together with dimethylaminoethanol. The effectiveness of Tricutan in improving skin firmness and elasticity in photoaged facial skin was examined in a randomised, placebo-controlled, double-blind, split-face study in 28 women, 34-67 years old. Treatment with Tricutan and placebo was given for 4 weeks. Skin firmness and elasticity was evaluated using the speed of propagation of ultrasound shear waves in the skin as end point (Reviscometer RVM 600). The study was completed by 25 women. The Tricutan treatment resulted in a significantly reduced propagation speed indicating increased firmness. There was no immediate effect by Tricutan application on propagation speed. At self evaluation the women evaluated the treatment effect of Tricutan to be significantly better than the treatment effect of placebo. The clinical evaluation also showed Tricutan to give a significantly better treatment result than placebo. Tolerance to Tricutan was generally good. However, three women did not complete the study because of mild irritative contact dermatitis. The results show that Tricutan can increase skin firmness both objectively and subjectively. Further studies are warranted, especially to investigate if Tricutan can delay the need for surgical face-lift procedures.
Tricutan是一种草药提取物的复方产品，传统上用于治疗皮肤疾病，还含有二甲基乙醇胺。在一项针对28名年龄在34至67岁之间女性的随机、安慰剂对照、双盲、面部半侧对照研究中，考察了Tricutan改善光老化面部皮肤紧致度和弹性的有效性。Tricutan和安慰剂治疗均持续4周。以皮肤中超声剪切波的传播速度作为终点指标（Reviscometer RVM 600）来评估皮肤紧致度和弹性。该研究由25名女性完成。Tricutan治疗导致传播速度显著降低，表明紧致度增加。涂抹Tricutan对传播速度没有即刻影响。在自我评估中，女性们认为Tricutan的治疗效果明显优于安慰剂。临床评估也显示Tricutan的治疗效果明显优于安慰剂。对Tricutan的耐受性总体良好。然而，有三名女性因轻度刺激性接触性皮炎而未完成研究。结果表明，Tricutan在客观和主观上都能增加皮肤紧致度。有必要进行进一步研究，特别是调查Tricutan是否可以延缓面部整形手术的需求。
