Reddy K Srinath, Prabhakaran Dorairaj, Jeemon Panniyammakal, Thankappan K R, Joshi Prashant, Chaturvedi Vivek, Ramakrishnan Lakshmy, Ahmed Farooque
Public Health Foundation of India, All India Institute of Medical Sciences, New Delhi 110029, India.
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16263-8. doi: 10.1073/pnas.0700933104. Epub 2007 Oct 8.
The inverse graded relationship of education and risk factors of coronary heart disease (CHD) has been reported from Western populations. To examine whether risk factors of CHD are predicted by level of education and influenced by the level of urbanization in Indian industrial populations, a cross-sectional survey (n = 19,973; response rate, 87.6%) was carried out among employees and their family members in 10 medium-to-large industries in highly urban, urban, and periurban regions of India. Information on behavioral, clinical, and biochemical risk factors of CHD was obtained through standardized instruments, and educational status was assessed in terms of the highest educational level attained. Data from 19,969 individuals were used for analysis. Tobacco use and hypertension were significantly more prevalent in the low- (56.6% and 33.8%, respectively) compared with the high-education group (12.5% and 22.7%, respectively; P < 0.001). However, dyslipidemia prevalence was significantly higher in the high-education group (27.1% as compared with 16.9% in the lowest-education group; P < 0.01). When stratified by the level of urbanization, industrial populations located in highly urbanized centers were observed to have an inverse graded relationship (i.e., higher-education groups had lower prevalence) for tobacco use, hypertension, diabetes, and overweight, whereas in less-urbanized locations, we found such a relationship only for tobacco use and hypertension. This study indicates the growing vulnerability of lower socioeconomic groups to CHD. Preventive strategies to reduce major CHD risk factors should focus on effectively addressing these social disparities.
西方人群中已报道了教育程度与冠心病(CHD)危险因素之间的反向分级关系。为了研究在印度工业人群中,冠心病危险因素是否由教育水平预测,并受城市化水平影响,我们在印度高度城市化、城市化和城郊地区的10家中型至大型工业企业的员工及其家庭成员中开展了一项横断面调查(n = 19,973;应答率87.6%)。通过标准化工具获取冠心病行为、临床和生化危险因素的信息,并根据所达到的最高教育水平评估教育状况。19,969人的数据用于分析。与高教育组相比,低教育组(分别为56.6%和33.8%)的烟草使用和高血压患病率显著更高(分别为12.5%和22.7%;P < 0.001)。然而,高教育组的血脂异常患病率显著更高(27.1%,而最低教育组为16.9%;P < 0.01)。按城市化水平分层时,位于高度城市化中心的工业人群在烟草使用、高血压、糖尿病和超重方面呈现反向分级关系(即高教育组患病率较低),而在城市化程度较低的地区,我们仅发现烟草使用和高血压存在这种关系。这项研究表明社会经济地位较低群体患冠心病的易感性在增加。降低主要冠心病危险因素的预防策略应侧重于有效解决这些社会差异问题。