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抗菌和抗真菌剂的研究。IX——新型N-芳基吡咯的合成及微生物活性

Research on antibacterial and antifungal agents. IX--Synthesis and microbiological activity of new N-arylpyrroles.

作者信息

Porretta G C, Biava M, Fioravanti R, Villa A, Simonetti N

机构信息

Dipartimento di Studi di Chimica, Università Degli Studi di Roma La Sapienza, Italy.

出版信息

Farmaco. 1991 Jul-Aug;46(7-8):987-95.

PMID:1793479
Abstract

The synthesis and antiblastomycete activity of new N-arylpyrrole derivatives are reported. Antimicrobial data in comparison with those obtained with pyrrolnitrin and miconazole showed that all tested compounds possess weak or poor activity. The obtained results are discussed on the basis of structure-activity relationships.

摘要

报道了新型N-芳基吡咯衍生物的合成及其抗芽生菌活性。与硝吡咯菌素和咪康唑所得结果相比的抗菌数据表明，所有测试化合物均具有较弱或较差的活性。基于构效关系对所得结果进行了讨论。

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