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[A substance with antibacterial and antifungal activity. V. Synthesis and microbiological activity of new derivatives of 1,5-diarylpyrrole].

作者信息

Scalzo M, Porretta G C, Chimenti F, Bolasco A, Casanova M C, Simonetti N, Villa A

机构信息

Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, Roma.

出版信息

Farmaco Sci. 1988 Sep;43(9):677-91.

PMID:3229494
Abstract

The synthesis and antifungal activities of new 1,5-diarylpyrrole derivatives are reported. The N-methylpiperazinyl substituent must be regarded as fundamental to activity. Furthermore the presence of substituents on the para position of the two phenyl rings and the presence of halogen atoms can be considered strengthening factors to microbiological activity. The results obtained are discussed on the basis of structure-activity relationship.

摘要

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