[具有抗菌和抗真菌活性的物质。VII。1,5-二芳基吡咯新衍生物的合成及微生物活性]
[Substances with antibacterial and antifungal activity. VII. Synthesis and microbiologic activity of new derivatives of 1,5-diarylpyrrole].
作者信息
Porretta G C, Cerreto F, Fioravanti R, Biava M, Scalzo M, Simonetti N, D'Auria F D
出版信息
Farmaco. 1989 Jan;44(1):65-76.
PMID:2742722
Abstract
The synthesis and antifungal activities of new 1,5-diarylpyrrole derivatives are reported. Antimicrobial data in comparison with pyrrolnitrin show that N-methylpiperazinylamides exhibit very poor activity against Candida albicans and Candida sp. while acid and ester derivatives are inactive. Vice-versa many acid or amide derivatives show interesting antibacterial activity. The results obtained are discussed on the basis of structure-activity relationships.
摘要
报道了新型1,5-二芳基吡咯衍生物的合成及其抗真菌活性。与硝吡咯菌素相比的抗菌数据表明，N-甲基哌嗪基酰胺对白色念珠菌和念珠菌属表现出非常弱的活性，而酸和酯衍生物则无活性。反之，许多酸或酰胺衍生物表现出有趣的抗菌活性。根据构效关系对所得结果进行了讨论。
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