Porretta G C, Cerreto F, Fioravanti R, Biava M, Scalzo M, Simonetti N, D'Auria F D
Farmaco. 1989 Jan;44(1):65-76.
The synthesis and antifungal activities of new 1,5-diarylpyrrole derivatives are reported. Antimicrobial data in comparison with pyrrolnitrin show that N-methylpiperazinylamides exhibit very poor activity against Candida albicans and Candida sp. while acid and ester derivatives are inactive. Vice-versa many acid or amide derivatives show interesting antibacterial activity. The results obtained are discussed on the basis of structure-activity relationships.
报道了新型1,5-二芳基吡咯衍生物的合成及其抗真菌活性。与硝吡咯菌素相比的抗菌数据表明，N-甲基哌嗪基酰胺对白色念珠菌和念珠菌属表现出非常弱的活性，而酸和酯衍生物则无活性。反之，许多酸或酰胺衍生物表现出有趣的抗菌活性。根据构效关系对所得结果进行了讨论。
