Buscemi Silvio, Verga Salvatore, Caimi Gregorio, Cerasola Giovanni
Dipartimento di Medicina Interna, Malattie Cardiovascolari e NefroUrologiche, Facoltà di Medicina, Università di Palermo, Italy.
Clin Nutr. 2007 Dec;26(6):806-9. doi: 10.1016/j.clnu.2007.08.010. Epub 2007 Oct 23.
BACKGROUND & AIMS: The metabolic syndrome is associated with central accumulation of fat. Previous studies showed that some obese subjects are characterized by a sparing energy metabolism. The aim of this study was to investigate whether obese subjects with metabolic syndrome have a lower resting metabolic rate than obese subjects without metabolic syndrome.
Forty obese subjects were divided into three groups according to the presence of metabolic syndrome and type 2 diabetes; 15 non-obese healthy control subjects were also enrolled. Body composition (bio-impedance analysis) and resting metabolic rate (indirect calorimetry) were performed.
The group with metabolic syndrome exhibited a significantly lower resting metabolic rate adjusted for fat-free mass with respect to the control group and the obese group without metabolic syndrome (respectively: 108+/-3 vs. 118+/-3, p<0.01 and 123+/-3 kJ/kg fat-free mass 24 h, p<0.01; mean+/-sem). The obese group with metabolic syndrome and type 2 diabetes (T2D) had a not different adjusted resting metabolic rate (114+/-6 kJ/kg fat-free mass 24h) with respect to other groups.
An energy sparing condition seems to characterize non-diabetic obese subjects with metabolic syndrome.
代谢综合征与脂肪的中心性堆积有关。先前的研究表明，一些肥胖受试者具有节约能量的代谢特征。本研究的目的是调查患有代谢综合征的肥胖受试者的静息代谢率是否低于无代谢综合征的肥胖受试者。
根据代谢综合征和2型糖尿病的情况，将40名肥胖受试者分为三组；还纳入了15名非肥胖健康对照受试者。进行了身体成分分析（生物电阻抗分析）和静息代谢率测定（间接测热法）。
与对照组和无代谢综合征的肥胖组相比，代谢综合征组经去脂体重校正后的静息代谢率显著降低（分别为：108±3 vs. 118±3，p<0.01；以及123±3 kJ/kg去脂体重24小时，p<0.01；均值±标准误）。患有代谢综合征和2型糖尿病（T2D）的肥胖组与其他组相比，经校正后的静息代谢率无差异（114±6 kJ/kg去脂体重24小时）。
能量节约状态似乎是患有代谢综合征的非糖尿病肥胖受试者的特征。
