Xu Jie-Kun, Kurihara Hiroshi, Zhao Liang, Yao Xin-Sheng
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
J Asian Nat Prod Res. 2007 Sep-Dec;9(6-8):665-72. doi: 10.1080/10286020601103155.
The central nervous system activities of theacrine (1,3,7,9-tetramethyluric acid), a purine alkaloid which is abundantly present in Camellia assamica var. kucha, were investigated in ambulatory activity, pentobarbital-induced sleep and forced swimming test in mice, compared with two other purine alkaloids, caffeine and theobromine. Caffeine treatment led to a marked increase in the ambulatory activity accompanied with decreasing of the immobility time in forced swimming test at both 10 and 30 mg/kg. Under the same conditions, neither theacrine nor theobromine showed obvious excited efficacy. Both doses of theacrine could significantly prolong the sleeping time induced by pentobarbital, while caffeine and theobromine exhibited an inverted effect. These results indicated that theacrine possessed potent sedative and hypnotic properties and its central nervous system effects were different from those of caffeine and theobromine.
茶氨酸（1,3,7,9 - 四甲基尿酸）是一种嘌呤生物碱，大量存在于普洱茶变种库车茶中。本研究在小鼠的自主活动、戊巴比妥诱导睡眠和强迫游泳试验中，对茶氨酸的中枢神经系统活性进行了研究，并与另外两种嘌呤生物碱咖啡因和可可碱进行了比较。咖啡因处理在10和30 mg/kg剂量下均导致自主活动显著增加，同时强迫游泳试验中的不动时间减少。在相同条件下，茶氨酸和可可碱均未表现出明显的兴奋作用。两种剂量的茶氨酸均可显著延长戊巴比妥诱导的睡眠时间，而咖啡因和可可碱则表现出相反的作用。这些结果表明，茶氨酸具有强大的镇静和催眠特性，其对中枢神经系统的作用与咖啡因和可可碱不同。
