Furth J, Chrétien M, Lis M, Bélanger A, Moy P, Grauman J
Arch Pathol. 1975 Nov;99(11):572-81.
The affinity for antiserum to the multipotent lipotropic hormone (beta-LPH) was tested by immunohistochemical staining of all known cell types in normal and certain abnormal mouse, rat, and human pituitaries. Results indicate that beta-LPH has ACTH, MSH, LH and StH(GH) immunologically cross-reacting determinants. Affinities of anti-LPH for TtH and MtH (prolactin) were not detected in normal pituitaries, but thyrotropic tumor cells reacted with anti-LPH. Absorption experiments confirm that the single polypeptide hormone of the pituitary, beta-LPH, is coded for ACTH and MSH activities. The multi-functional hormone, LPH probably is secreted by the adrenotropes. In addition to ACTH and MSH, it probably contains other antigenic and biologic determinants. Some of these may accentuate its lipotropic activities; others may be incidental. These are points calling for further correlated structural, biologic, and immunologic investigations.
通过对正常及某些异常小鼠、大鼠和人类垂体中所有已知细胞类型进行免疫组织化学染色，检测了抗血清对多能促脂激素（β - 促脂素）的亲和力。结果表明，β - 促脂素具有促肾上腺皮质激素（ACTH）、促黑素（MSH）、促黄体生成素（LH）和促生长激素（StH，即生长激素GH）的免疫交叉反应决定簇。在正常垂体中未检测到抗促脂素对促甲状腺激素（TtH）和促乳素（MtH，即催乳素）的亲和力，但促甲状腺肿瘤细胞与抗促脂素发生反应。吸收实验证实，垂体的单一多肽激素β - 促脂素编码了ACTH和MSH的活性。多功能激素促脂素可能由促肾上腺皮质细胞分泌。除了ACTH和MSH外，它可能还含有其他抗原性和生物学决定簇。其中一些可能会增强其促脂活性；其他的可能是偶然的。这些都是需要进一步进行相关结构、生物学和免疫学研究的要点。
