Fujihara K, Itoyama Y, Yu F, Kubo C, Goto I
Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Neurol Sci. 1991 Sep;105(1):99-107. doi: 10.1016/0022-510x(91)90125-q.
To investigate the cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied the cytotoxic T lymphocytes (CTL) activity against an HTLV-I infected human T cell line (MT-2) and the natural killer (NK) cell activity in 15 HAM patients, 6 HTLV-I carriers, and 15 controls. The activity of CTL against MT-2 cells was found to be significantly elevated in HAM compared with that in the controls. This cytotoxicity in HAM was higher than in HTLV-I carriers, although the difference was not statistically significant. There was an HLA class I restriction in this CTL activity against MT-2 cells in HAM. On the other hand, NK cell activity was significantly lower in HAM than in controls. Cold target inhibition studies suggested that NK cells could not lyse MT-2 cells effectively. There was a positive correlation between the CTL activity against MT-2 cells and the serum antibody titers to HTLV-I in HAM.
为了研究人类嗜T淋巴细胞病毒I型相关脊髓病/热带痉挛性截瘫（HAM/TSP）中针对HTLV-I感染的T淋巴细胞的细胞免疫监视，我们研究了15例HAM患者、6例HTLV-I携带者和15名对照者针对HTLV-I感染的人T细胞系（MT-2）的细胞毒性T淋巴细胞（CTL）活性以及自然杀伤（NK）细胞活性。结果发现，与对照组相比，HAM患者中针对MT-2细胞的CTL活性显著升高。尽管差异无统计学意义，但HAM中的这种细胞毒性高于HTLV-I携带者。HAM中针对MT-2细胞的这种CTL活性存在HLA I类限制。另一方面，HAM患者的NK细胞活性显著低于对照组。冷靶抑制研究表明，NK细胞不能有效地裂解MT-2细胞。HAM中针对MT-2细胞的CTL活性与HTLV-I血清抗体滴度之间存在正相关。
