Nielson Carrie M, Harris Robin B, Dunne Eileen F, Abrahamsen Martha, Papenfuss Mary R, Flores Roberto, Markowitz Lauri E, Giuliano Anna R
Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health, Tucson, AZ, USA.
J Infect Dis. 2007 Oct 15;196(8):1137-45. doi: 10.1086/521632. Epub 2007 Sep 17.
Human papillomavirus (HPV) is strongly associated with cervical and other anogenital cancers. Identification of risk factors for HPV infection in men may improve our understanding of HPV transmission and prevention.
HPV testing for 37 types was conducted in 463 men 18-40 years old recruited from 2 US cities. The entire anogenital region and semen were sampled. A self-administered questionnaire was completed. Multivariate logistic regression aided the identification of independent risk factors for any HPV type, oncogenic HPV types, and nononcogenic HPV types.
Prevalence was 65.4% for any HPV, 29.2% for oncogenic HPV, and 36.3% for nononcogenic HPV. Factors significantly associated with any HPV were smoking > or =10 cigarettes per day (odds ratio [OR], 2.3 [95% confidence interval {CI}, 1.0-5.3]) and lifetime number of female sex partners (FSPs) (OR for > or =21, 2.5 [95% CI, 1.3-4.6]), and factors significantly associated with oncogenic HPV were lifetime number of FSPs (OR for > or =21, 7.4 [95% CI, 3.4-16.3]) and condom use during the past 3 months (OR for more than half the time, 0.5 [95% CI, 0.3-0.8]). For nononcogenic HPV, a significant association was found for number of FSPs during the past 3 months (OR for > or =2, 2.9 [95% CI, 1.4-6.3]).
Lifetime and recent number of FSPs, condom use, and smoking were modifiable risk factors associated with HPV infection in men.
人乳头瘤病毒（HPV）与宫颈癌及其他肛门生殖器癌症密切相关。确定男性HPV感染的风险因素可能有助于我们更好地理解HPV的传播及预防。
对从美国2个城市招募的463名18至40岁男性进行37种HPV类型的检测。对整个肛门生殖器区域及精液进行采样。完成一份自行填写的问卷。多因素逻辑回归分析有助于确定任何HPV类型、致癌性HPV类型及非致癌性HPV类型的独立风险因素。
任何HPV的感染率为65.4%，致癌性HPV为29.2%，非致癌性HPV为36.3%。与任何HPV显著相关的因素包括每天吸烟≥10支（比值比[OR]，2.3[95%置信区间{CI}，1.0 - 5.3]）及女性性伴侣（FSP）的终生数量（≥21个时的OR，2.5[95%CI，1.3 - 4.6]），与致癌性HPV显著相关的因素为FSP的终生数量（≥21个时的OR，7.4[95%CI，3.4 - 16.3]）及过去3个月使用避孕套的情况（使用时间超过一半时的OR，0.5[95%CI，0.3 - 0.8]）。对于非致癌性HPV，过去3个月的FSP数量存在显著关联（≥2个时的OR，2.9[95%CI，1.4 - 6.3]）。
FSP的终生数量及近期数量、避孕套使用情况和吸烟是与男性HPV感染相关的可改变风险因素。
