Synthesis and antidepressant evaluation of three para-benzoquinone mono-oximes and their oxy derivatives.
作者信息
de Sousa Damião Pergentino, Schefer Renata Rabelo, Brocksom Ursula, Brocksom Timothy John
机构信息
Laboratório de Química Bio-Orgânica, Departamento de Química, Universidade Federal de São Carlos, Caixa Postal 676, 13565-905 São Carlos, SP, Brazil.
出版信息
Molecules. 2006 Mar 10;11(2):148-55. doi: 10.3390/11020148.
Abstract
A series of three para-benzoquinone mono-oximes and four oxy-derivatives were prepared and tested for their antidepressant properties. The (4E) oxime of 2-isopropyl-5-methyl-para-benzoquinone (4) and the corresponding 2-diethylamino-ethyl derivative (10) present antidepressant activities and were slightly more potent than the reference standard.
摘要
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本文引用的文献
1
A simplified method of evaluating dose-effect experiments.
J Pharmacol Exp Ther. 1949 Jun;96(2):99-113.
2
Stereospecific antitumor activity of radicicol oxime derivatives.
Cancer Chemother Pharmacol. 2001 Dec;48(6):435-45. doi: 10.1007/s002800100373.
3
Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities.
Eur J Med Chem. 2001 May;36(5):421-33. doi: 10.1016/s0223-5234(01)01223-5.
4
O-[2-hydroxy-3-(dialkylamino)propyl]ethers of (+)-1,7,7-trimethyl bicyclo[2.2.1]heptan-2-one oxime (camphor oxime) with analgesic and antiarrhythmic activities.
Farmaco. 2000 Jun-Jul;55(6-7):495-8. doi: 10.1016/s0014-827x(00)00065-3.
5
2,3-Butanedione monoxime protects mice against the convulsant effect of picrotoxin by facilitating GABA-activated currents.
Brain Res. 1995 Apr 24;678(1-2):110-6. doi: 10.1016/0006-8993(95)00175-p.
6
The validity of animal models of depression.
Psychopharmacology (Berl). 1984;83(1):1-16. doi: 10.1007/BF00427414.
7
Depression: a new animal model sensitive to antidepressant treatments.
Nature. 1977 Apr 21;266(5604):730-2. doi: 10.1038/266730a0.
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