对重度抑郁症和品行障碍的常见遗传及环境影响。
Common genetic and environmental influences on major depressive disorder and conduct disorder.
作者信息
Subbarao Anjali, Rhee Soo Hyun, Young Susan E, Ehringer Marissa A, Corley Robin P, Hewitt John K
机构信息
Department of Psychology, University of Colorado, Boulder, CO, USA.
出版信息
J Abnorm Child Psychol. 2008 Apr;36(3):433-44. doi: 10.1007/s10802-007-9189-1. Epub 2007 Oct 27.
Abstract
The evidence for common genetic and environmental influences on conduct disorder (CD) and major depressive disorder (MDD) in adolescents was examined. A sample of 570 monozygotic twin pairs, 592 dizygotic twin pairs, and 426 non-twin siblings, aged 12-18 years, was recruited from the Colorado Twin Registry. For the past year data, there was a significant correlation between the genetic influences on MDD and CD and, for the lifetime data, there was a significant correlation between the genetic influences on MDD and CD, and a significant correlation between the nonshared environmental influences on MDD and CD. Our results suggest that some genetic factors will increase an individual's vulnerability to both MDD and CD in adolescence.
摘要
研究了青少年品行障碍（CD）和重度抑郁症（MDD）受共同遗传和环境影响的证据。从科罗拉多双胞胎登记处招募了570对同卵双胞胎、592对异卵双胞胎和426名非双胞胎兄弟姐妹，年龄在12至18岁之间。对于过去一年的数据，MDD和CD的遗传影响之间存在显著相关性；对于终生数据，MDD和CD的遗传影响之间存在显著相关性，且MDD和CD的非共享环境影响之间也存在显著相关性。我们的结果表明，一些遗传因素会增加个体在青春期患MDD和CD的易感性。
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