一项关于缓冲0.9%和3%氯化钠鼻喷雾剂对纤毛摆动频率影响的双盲、随机、对照研究。
A blinded, randomized, controlled study on the effect of buffered 0.9% and 3% sodium chloride intranasal sprays on ciliary beat frequency.
作者信息
Wabnitz David A M, Wormald Peter-John
机构信息
Department of Surgery, Otolaryngology-Head and Neck Surgery, Adelaide and Flinders Universities, Adelaide, South Australia.
出版信息
Laryngoscope. 2005 May;115(5):803-5. doi: 10.1097/01.MLG.0000157284.93280.F5.
BACKGROUND
There are conflicting reports regarding the effect of intranasal saline sprays on the various components of the mucociliary clearance system. This study evaluates the effect of normal saline and hypertonic saline on the ciliary beat frequency (CBF).
METHODS
Eight healthy volunteers were randomized to receive 0.9% saline spray to one nostril and 3.0% saline spray to the other. Ciliated cells were collected, and the CBF was calculated using computerized microphotometry.
RESULTS
Although neither solution significantly altered the CBF from baseline measurements, there was a significant difference between the CBFs of the two solutions at 5 minutes postadministration (9.1 Hz with 0.9% saline, 10.1 Hz with 3.0% saline, P < .05). This was a transient effect and was not seen when cells were examined at 60 minutes postadministration.
CONCLUSION
The administration of hypertonic saline results in a significantly faster CBF 5 minutes after administration. This effect is not seen 60 minutes after administration.
背景
关于鼻内盐水喷雾对黏液纤毛清除系统各组成部分的影响，存在相互矛盾的报道。本研究评估生理盐水和高渗盐水对纤毛摆动频率（CBF）的影响。
方法
八名健康志愿者被随机分为一侧鼻孔接受0.9%盐水喷雾，另一侧鼻孔接受3.0%盐水喷雾。收集纤毛细胞，并使用计算机显微光度法计算CBF。
结果
尽管两种溶液均未使CBF较基线测量值发生显著改变，但给药后5分钟时两种溶液的CBF存在显著差异（0.9%盐水组为9.1Hz，3.0%盐水组为10.1Hz，P <.05）。这是一种短暂效应，给药后60分钟检查细胞时未观察到这种效应。
结论
高渗盐水给药后5分钟会使CBF显著加快。给药后60分钟未观察到这种效应。
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