Keojampa Bounmany K, Nguyen Mai Hoang, Ryan Matthew W
The University of Texas Medical Branch, TX 77555-0521, USA.
Otolaryngol Head Neck Surg. 2004 Nov;131(5):679-82. doi: 10.1016/j.otohns.2004.05.026.
To compare the effects of buffered hypertonic and buffered normal saline nasal spray on mucociliary clearance and nasal airway patency.
Double-blind trial with subjects acting as their own controls. Tertiary care academic medical center.
Buffered hypertonic saline and buffered normal saline both improved saccharine clearance times ( P < 0.0001 for buffered hypertonic and P = 0.002 for buffered normal saline). Buffered hypertonic saline improved saccharine clearance times more than buffered normal saline (39.6% vs 24.1%, P = 0.007). Neither buffered hypertonic nor buffered normal saline significantly affected nasal airway patency.
Both buffered hypertonic and buffered normal saline nasal spray significantly improved saccharine clearance times without affecting nasal airway patency. Buffered hypertonic saline affected saccharine clearance times to a greater degree than buffered normal saline.
Buffered hypertonic and buffered normal saline sprays both improve mucociliary clearance and should therefore be beneficial in conditions such as rhinitis and sinusitis, which are associated with disruption of mucociliary clearance. However, these sprays do not appear to affect the nasal airway. Patients may therefore benefit from other treatments for "nasal congestion."
B-2.
比较缓冲高渗盐水鼻腔喷雾剂和缓冲等渗盐水鼻腔喷雾剂对黏液纤毛清除功能及鼻气道通畅性的影响。
双盲试验，受试者自身作为对照。三级医疗学术医学中心。
缓冲高渗盐水和缓冲等渗盐水均能改善糖精清除时间（缓冲高渗盐水P<0.0001，缓冲等渗盐水P = 0.002）。缓冲高渗盐水比缓冲等渗盐水更能改善糖精清除时间（39.6% 对24.1%，P = 0.007）。缓冲高渗盐水和缓冲等渗盐水均未对鼻气道通畅性产生显著影响。
缓冲高渗盐水鼻腔喷雾剂和缓冲等渗盐水鼻腔喷雾剂均能显著改善糖精清除时间，且不影响鼻气道通畅性。缓冲高渗盐水对糖精清除时间的影响程度大于缓冲等渗盐水。
缓冲高渗盐水喷雾剂和缓冲等渗盐水喷雾剂均能改善黏液纤毛清除功能，因此在与黏液纤毛清除功能受损相关的疾病如鼻炎和鼻窦炎中可能有益。然而，这些喷雾剂似乎不影响鼻气道。因此，患者可能需要其他治疗“鼻塞”的方法。
B-2
