Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, Vietnam.
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Hanoi 100803, Vietnam.
Molecules. 2019 Oct 24;24(21):3830. doi: 10.3390/molecules24213830.
Marine microorganisms are an invaluable source of novel active secondary metabolites possessing various biological activities. In this study, the extraction and isolation of the marine sediment species collected in Vietnam yielded ten secondary metabolites, including sporogen AO-1 (), 3-indolecarbaldehyde (), 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol (), 2-[(2-hydroxypropanoyl)amino]benzamide (), 4-hydroxybenzandehyde (), chrysogine (), 3-acetyl-4-hydroxycinnoline (), acid 1H-indole-3-acetic (), cyclo (Tyr-Trp) (), and 2',3'-dihydrosorbicillin (). Their structures were identified by the analysis of 1D and 2D NMR data. Among the isolated compounds, 2-[(5-methyl-1,4-dioxan-2-yl)methoxy]ethanol () showed a strong inhibitory effect against with a minimum inhibitory concentration value of 32 µg/mL. Both 2-[(2-hydroxypropanoyl)amino]benzamide () and 4-hydroxybenzandehyde () selectively inhibited with minimum inhibitory concentration values of 16 and 8 µg/mL, respectively. 2',3'-Dihydrosorbicillin () potentially inhibited α-glucosidase activity at a concentration of 2.0 mM (66.31%).
海洋微生物是具有各种生物活性的新型活性次生代谢物的宝贵来源。在这项研究中，从越南采集的海洋沉积物中提取和分离得到了十种次生代谢物，包括孢子生成素 AO-1()、3-吲哚甲醛()、2-[(5-甲基-1,4-二恶烷-2-基)甲氧基]乙醇()、2-[(2-羟基丙酰基)氨基]苯甲酰胺()、4-羟基苯甲醛()、chrysogine()、3-乙酰基-4-羟基喹啉()、酸 1H-吲哚-3-乙酸()、环(Tyr-Trp)()和 2',3'-二氢桑辛素()。通过 1D 和 2D NMR 数据分析鉴定了它们的结构。在分离得到的化合物中，2-[(5-甲基-1,4-二恶烷-2-基)甲氧基]乙醇()对 表现出强烈的抑制作用，最小抑菌浓度值为 32 µg/mL。2-[(2-羟基丙酰基)氨基]苯甲酰胺()和 4-羟基苯甲醛()分别对 具有选择性抑制作用，最小抑菌浓度值分别为 16 和 8 µg/mL。2',3'-二氢桑辛素()在 2.0 mM 浓度下可能抑制α-葡萄糖苷酶活性(66.31%)。
