Haldar Jayanta, Chen Jianzhu, Tumpey Terrence M, Gubareva Larisa V, Klibanov Alexander M
Department of Chemistry and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Biotechnol Lett. 2008 Mar;30(3):475-9. doi: 10.1007/s10529-007-9565-5. Epub 2007 Oct 31.
Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.
涂有疏水性长链聚阳离子N，N-十二烷基甲基聚乙烯亚胺（N，N-十二烷基甲基-PEI）的载玻片对水传播的甲型流感病毒具有高度致死性，这些病毒不仅包括野生型人类和禽类毒株，还包括对目前使用的抗流感药物耐药的神经氨酸酶突变体。
