Steiner G
Division of Endocrinology and Metabolism, Toronto Hospital, Ontario, Canada.
Diabetes Care. 1991 Nov;14(11):1077-81. doi: 10.2337/diacare.14.11.1077.
To determine whether reducing triglyceride concentrations in humans reduces serum insulin levels and consider the implications of this for the insulin resistance of hypertriglyceridemia.
Insulin and glucose levels were determined during an oral glucose tolerance test (OGTT) in 14 volunteers who had a range of basal triglyceride levels. A double-blind crossover design was used to study active and placebo gemfibrozil and relate triglyceride changes to insulin and glucose levels. Diet and weight were kept constant.
Glucose concentrations during OGTT were the same in both treatment periods. Insulin concentrations were reduced in proportion to reductions in triglyceride.
Triglyceride reduction in hypertriglyceridemic patients is associated with a decrease in serum insulin. This does not appear to be a direct effect of gemfibrozil, because it does not occur without a sufficient fall in triglyceride levels. Because glucose concentration remains the same despite the reduced insulin, the triglyceride reduction may result in greater sensitivity to insulin. Treatment of hypertriglyceridemia may break a vicious and potentially atherogenic cycle of hypertriglyceridemia and hyperinsulinemia.
确定降低人体甘油三酯浓度是否会降低血清胰岛素水平，并探讨其对高甘油三酯血症胰岛素抵抗的影响。
在口服葡萄糖耐量试验（OGTT）期间，对14名基础甘油三酯水平各异的志愿者测定胰岛素和葡萄糖水平。采用双盲交叉设计研究活性吉非贝齐和安慰剂吉非贝齐，并将甘油三酯变化与胰岛素和葡萄糖水平相关联。饮食和体重保持恒定。
两个治疗期OGTT期间的葡萄糖浓度相同。胰岛素浓度与甘油三酯的降低成比例降低。
高甘油三酯血症患者甘油三酯的降低与血清胰岛素的降低有关。这似乎不是吉非贝齐的直接作用，因为没有足够的甘油三酯水平下降就不会发生这种情况。尽管胰岛素降低，但葡萄糖浓度保持不变，因此甘油三酯的降低可能导致对胰岛素的敏感性增加。高甘油三酯血症的治疗可能会打破高甘油三酯血症和高胰岛素血症的恶性循环以及潜在的致动脉粥样硬化循环。
