先兆子痫中的脂肪酸、抗氧化剂与氧化应激
Fatty acids, antioxidants, and oxidative stress in pre-eclampsia.
作者信息
Mehendale Savita, Kilari Anitha, Dangat Kamini, Taralekar Vaishali, Mahadik Sahebarao, Joshi Sadhana
机构信息
Department of Obstetrics and Gynecology, Bharati Medical College Hospital, Bharati Vidyapeeth University, Maharashtra, India.
出版信息
Int J Gynaecol Obstet. 2008 Mar;100(3):234-8. doi: 10.1016/j.ijgo.2007.08.011. Epub 2007 Oct 31.
OBJECTIVE
To investigate whether free radical-mediated membrane lipid peroxidation may be implicated in the pathogenesis of pre-eclampsia.
METHODS
A prospective study using a sample of 55 healthy pregnant women and 60 pre-eclamptic women recruited at Bharati Medical Hospital, Pune, India. Maternal and cord samples were examined for (red blood cells and plasma) fatty acid profiles, antioxidants, and oxidative stress levels. Mean values were compared between case and control groups using the t test and Wilcoxon rank test.
RESULTS
Pre-eclamptic women showed reduced total omega-3 fatty acids (P<0.05), increased omega-6:omega-3 ratio (P<0.05), higher oxidative stress (P<0.05), and lower antioxidant (P<0.05) levels. Similar trends were also observed in cord samples.
CONCLUSION
Reduced antioxidants and increased oxidative stress leading to impaired essential polyunsaturated fatty acid levels may be a key factor in the development of pre-eclampsia.
目的
研究自由基介导的膜脂质过氧化是否与子痫前期的发病机制有关。
方法
一项前瞻性研究，样本来自印度浦那巴拉蒂医院招募的55名健康孕妇和60名子痫前期患者。检测母体和脐带样本（红细胞和血浆）的脂肪酸谱、抗氧化剂和氧化应激水平。使用t检验和威尔科克森秩和检验比较病例组和对照组的平均值。
结果
子痫前期患者的总ω-3脂肪酸减少（P<0.05），ω-6:ω-3比值增加（P<0.05），氧化应激水平较高（P<0.05），抗氧化剂水平较低（P<0.05）。在脐带样本中也观察到类似趋势。
结论
抗氧化剂减少和氧化应激增加导致必需多不饱和脂肪酸水平受损可能是子痫前期发生发展的关键因素。
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