Bakheit K H, Ghebremeskel K, Pol K, Elbashir M I, Adam I
Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
J Obstet Gynaecol. 2010 Feb;30(2):151-4. doi: 10.3109/01443610903391005.
A case-control study was conducted in Khartoum hospital, Sudan to compare omega-3 and omega-6 fatty acids profile in three phospholipid fractions (phosphatidylethanolamine, phosphatidylcholine and sphingomyelin) using gas chromatography in erythrocytes from 65 pre-eclamptic women and well-matched 60 healthy control pregnant women, both in the third trimester of pregnancy. While levels of arachidonic acid (omega-6 fatty acid) was significantly higher in women with pre-eclampsia in the sphingomyelin fraction only, the levels of eicosapentaenoic and docosahexaenoic acid (omega-3 fatty acid) in the three phospholipids fractions were significantly higher in women with pre-eclampsia than in the control group. Both omega-3 and omega-6 fatty acids profiles were not significantly different between patients with mild (diastolic blood pressure (DBP) <110 mmHg) and severe (DBP > or = 110 mmHg) pre-eclampsia.
在苏丹喀土穆医院进行了一项病例对照研究，以比较65例先兆子痫妇女和60例匹配良好的健康对照孕妇（均处于妊娠晚期）红细胞中三种磷脂组分（磷脂酰乙醇胺、磷脂酰胆碱和鞘磷脂）中的ω-3和ω-6脂肪酸谱。使用气相色谱法进行分析。结果显示，仅在鞘磷脂组分中，先兆子痫妇女的花生四烯酸（ω-6脂肪酸）水平显著更高；而先兆子痫妇女三种磷脂组分中的二十碳五烯酸和二十二碳六烯酸（ω-3脂肪酸）水平均显著高于对照组。轻度（舒张压（DBP）<110 mmHg）和重度（DBP>或=110 mmHg）先兆子痫患者之间的ω-3和ω-6脂肪酸谱均无显著差异。
