木腐真菌Xylaria sp. BCC 9653产生的细胞毒性代谢产物。

Cytotoxic metabolites from the wood-decayed fungus Xylaria sp. BCC 9653.

作者信息

Pongcharoen Wipapan, Rukachaisirikul Vatcharin, Isaka Masahiko, Sriklung Kanlayanee

机构信息

Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand.

出版信息

Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1647-8. doi: 10.1248/cpb.55.1647.

DOI:10.1248/cpb.55.1647

PMID:17978529

Abstract

Chemical investigation of the wood-decayed fungus Xylaria sp. BCC 9653 has led to the isolation of a new methyl aminobenzoate (1) together with eleven known compounds. The structures were established by analysis of spectroscopic data. Cytochalasin D (2), one of the known metabolites, exhibited potent cytotoxicity against African green monkey kidney fibroblast (Vero) cells with an IC(50) value of 0.19 microM.

摘要

对木腐菌炭角菌属Xylaria sp. BCC 9653进行化学研究，已分离出一种新的甲基氨基苯甲酸酯（1）以及十一种已知化合物。通过光谱数据分析确定了其结构。已知代谢产物之一的细胞松弛素D（2）对非洲绿猴肾成纤维细胞（Vero）表现出强大的细胞毒性，IC50值为0.19微摩尔。