来自内生真菌 Phomopsis sp. BCC 9789 的 Oblongolides。

Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789.

机构信息

National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phahonyothin Road, Klong 1, Klong Luang, Pathumthani 12120, Thailand.

出版信息

J Nat Prod. 2010 Jan;73(1):55-9. doi: 10.1021/np900650c.

DOI:10.1021/np900650c

PMID:20038128

Abstract

Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4alpha-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC50=14 microM) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC50 values of 37, 26, 32, and 60 microM. Cytotoxic activity against the BC cell line was also observed for compound 6, with an IC50 value of 48 microM.

摘要

从内生真菌 Phomopsis sp. BCC 9789 中分离得到了六个新的长梗霉素类化合物，W1、W2、X、Y、Z（1-3、6、7）和 2-去氧-4alpha-羟基长梗霉素 X（4），以及已知化合物长梗霉素（8）、长梗霉素 T、C 和 Q（5、9、10）和（-）-5-甲基麦角甾醇。化合物 7 表现出抗 HSV-1 活性（IC50=14 microM）和对 KB、BC、NCI-H187 和非恶性（Vero）细胞系的细胞毒性活性，其各自的 IC50 值分别为 37、26、32 和 60 microM。化合物 6 对 BC 细胞系也表现出细胞毒性活性，其 IC50 值为 48 microM。