Yasui Toshiyuki, Yamada Masayo, Irahara Minoru
The University of Tokushima Graduate School, Institutes of Health Biosciences, Department of Obstetrics and Gynecology.
Clin Calcium. 2007 Nov;17(11):1709-16.
Undercarboxylated osteocalcin (ucOC) is a sensitive marker of vitamin K (VK) status. Serum ucOC concentration in perimenopausal women is significantly higher than that in premenopausal women. In addition, serum ucOC concentration is closely associated with not only FSH concentration but also estradiol concentration. Serum ucOC concentration rapidly increases in women after bilateral oophorectomy. The effect of hormone therapy (HT) on alternate days on ucOC concentration is weaker than the effect of HT daily and ucOC concentration after 12 months of HT daily may be decreased due to the conversion of ucOC to carboxylated OC by the effect of VK through increased TG induced by oral conjugated equine estrogen (CEE) . Additionally, the effect of HT with transdermal estradiol on ucOC concentration in women is weaker than the effect of HT with oral CEE.
未羧化骨钙素（ucOC）是维生素K（VK）状态的敏感标志物。围绝经期女性的血清ucOC浓度显著高于绝经前女性。此外，血清ucOC浓度不仅与促卵泡生成素（FSH）浓度密切相关，还与雌二醇浓度密切相关。双侧卵巢切除术后女性的血清ucOC浓度迅速升高。隔日激素治疗（HT）对ucOC浓度的影响弱于每日HT，且由于口服结合马雌激素（CEE）诱导的甘油三酯（TG）增加，VK作用使ucOC转化为羧化骨钙素，每日HT 12个月后的ucOC浓度可能会降低。此外，经皮雌二醇HT对女性ucOC浓度的影响弱于口服CEE的HT。
