Hosoi Takayuki
Department of Clinical Research and Development, National Center for Geriatrics and Gerontology, Japan.
Clin Calcium. 2009 Dec;19(12):1815-21.
Importance of vitamin K has been suggested to maintain and improve bone strength. The serum concentration of undercarboxylated osteocalcin (ucOC) is utilized to assess the vitamin K status in bone metabolism. The clinical threshold for ucOC has been determined to discriminate the people at risk for fragility fractures from the view points of vitamin K metabolism. The measurement of ucOC would be useful to select the patients who require vitamin K(2) regimen and to assess the effectiveness of vitamin K(2) therapy.
维生素K对维持和改善骨强度的重要性已得到提示。未羧化骨钙素（ucOC）的血清浓度用于评估骨代谢中的维生素K状态。已确定ucOC的临床阈值，以便从维生素K代谢的角度区分脆性骨折风险人群。测量ucOC将有助于选择需要维生素K₂治疗方案的患者，并评估维生素K₂治疗的有效性。
