Ginzburg Valeriy V, Balijepalli Sudhakar
Research and Development, The Dow Chemical Company, Midland, MI 48674, USA.
Nano Lett. 2007 Dec;7(12):3716-22. doi: 10.1021/nl072053l. Epub 2007 Nov 6.
Interactions between nanoparticles and cell membranes may play a crucial role in determining the cytotoxicity of nanoparticles as well as their potential application as drug delivery vehicles or therapeutic agents. It has been shown that such interactions are often determined not by biochemical but by physicochemical factors (e.g., nanoparticle size, hydrophobicity, and surface charge density). Here, we propose a mesoscale thermodynamic model describing the transitions in membrane morphology observed after exposure to various types of nanoparticles. Our simulations demonstrate under which conditions (determined by particle size and hydrophilic/hydrophobic interactions) the particles can adsorb into the membrane or compromise the membrane integrity to result in the formation of nanosized holes. The model could be refined to include a more accurate description of various phospholipid membranes, and its results could be applied in the design of specific nanoparticles for various biomedical applications.
纳米颗粒与细胞膜之间的相互作用在决定纳米颗粒的细胞毒性以及它们作为药物递送载体或治疗剂的潜在应用方面可能起着至关重要的作用。研究表明，这种相互作用通常不是由生化因素而是由物理化学因素（例如纳米颗粒大小、疏水性和表面电荷密度）决定的。在此，我们提出了一个中尺度热力学模型，用于描述暴露于各种类型纳米颗粒后观察到的膜形态转变。我们的模拟表明，在哪些条件下（由颗粒大小和亲水/疏水相互作用决定）颗粒可以吸附到膜中或破坏膜的完整性，从而导致纳米尺寸孔洞的形成。该模型可以进一步完善，以更准确地描述各种磷脂膜，其结果可应用于设计用于各种生物医学应用的特定纳米颗粒。
