由p38丝裂原活化蛋白激酶活性的时间调节介导的昼夜节律性。
Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK.
作者信息
Vitalini Michael W, de Paula Renato M, Goldsmith Charles S, Jones Carol A, Borkovich Katherine A, Bell-Pedersen Deborah
机构信息
Center for Biological Clocks Research, Faculty of Genetics, and Program for the Biology of Filamentous Fungi, 3258 TAMU Department of Biology, Texas A&M University, College Station, TX 77843, USA.
出版信息
Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18223-8. doi: 10.1073/pnas.0704900104. Epub 2007 Nov 5.
Abstract
Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate cellular processes. Little is known about the output pathways. In this study, we show that the Neurospora crassa osmosensing MAPK pathway, essential for osmotic stress responses, is a circadian output pathway that regulates daily rhythms in the expression of downstream genes. Rhythmic activation of the highly conserved stress-activated p38-type MAPK [Osmotically Sensitive-2 (OS-2)] by the N. crassa circadian clock allows anticipation and preparation for hyperosmotic stress and desiccation that begin at sunrise. These results suggest a conserved role for MAPK pathways in circadian rhythmicity.
摘要
生物钟由中央振荡器、将外部信息传递给振荡器的输入通路以及使振荡器能够在时间上调节细胞过程的输出通路组成。关于输出通路我们了解甚少。在本研究中，我们表明粗糙脉孢菌的渗透压感应丝裂原活化蛋白激酶（MAPK）通路（对渗透应激反应至关重要）是一条调节下游基因每日节律表达的昼夜输出通路。粗糙脉孢菌生物钟对高度保守的应激激活p38型MAPK[渗透压敏感-2（OS-2）]的节律性激活，使得机体能够对日出时开始的高渗应激和干燥进行预测并做好准备。这些结果表明MAPK通路在昼夜节律中具有保守作用。
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