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本文引用的文献

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Comparative analysis of amphotericin B lipid complex and liposomal amphotericin B kinetics of lung accumulation and fungal clearance in a murine model of acute invasive pulmonary aspergillosis.两性霉素B脂质复合物与两性霉素B脂质体在急性侵袭性肺曲霉病小鼠模型中肺蓄积及真菌清除动力学的比较分析
Antimicrob Agents Chemother. 2007 Apr;51(4):1253-8. doi: 10.1128/AAC.01449-06. Epub 2007 Jan 29.
2
Aerosol granulocyte-macrophage colony-stimulating factor for pulmonary alveolar proteinosis.雾化吸入粒细胞巨噬细胞集落刺激因子治疗肺泡蛋白沉积症
Eur Respir J. 2006 Mar;27(3):585-93. doi: 10.1183/09031936.06.00058305.
3
Granulocyte-macrophage colony-stimulating factor inhalation therapy for patients with idiopathic pulmonary alveolar proteinosis: a pilot study; and long-term treatment with aerosolized granulocyte-macrophage colony-stimulating factor: a case report.粒细胞巨噬细胞集落刺激因子吸入疗法治疗特发性肺泡蛋白沉积症患者：一项试点研究；以及雾化粒细胞巨噬细胞集落刺激因子的长期治疗：一例病例报告。
Respirology. 2006 Jan;11 Suppl:S61-4. doi: 10.1111/j.1440-1843.2006.00811.x.
4
Murine model of invasive aspergillosis.侵袭性曲霉病的小鼠模型
Methods Mol Med. 2005;118:129-42. doi: 10.1385/1-59259-943-5:129.
5
Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity.卡泊芬净在侵袭性肺曲霉病小鼠模型中的药效学：浓度依赖性活性的证据。
J Infect Dis. 2004 Oct 15;190(8):1464-71. doi: 10.1086/424465. Epub 2004 Sep 10.
6
Polyene and cytokine treatment of experimental aspergillosis.
FEMS Immunol Med Microbiol. 2003 Dec 5;39(3):221-7. doi: 10.1016/S0928-8244(03)00230-X.
7
Aerosolized granulocyte macrophage colony-stimulating factor (GM-CSF) therapy in metastatic cancer.雾化粒细胞巨噬细胞集落刺激因子（GM-CSF）治疗转移性癌症。
Am J Clin Oncol. 2003 Oct;26(5):493-8. doi: 10.1097/01.coc.0000037664.04141.D0.
8
Itraconazole preexposure attenuates the efficacy of subsequent amphotericin B therapy in a murine model of acute invasive pulmonary aspergillosis.在急性侵袭性肺曲霉病小鼠模型中，伊曲康唑预先暴露会减弱随后两性霉素B治疗的疗效。
Antimicrob Agents Chemother. 2002 Oct;46(10):3208-14. doi: 10.1128/AAC.46.10.3208-3214.2002.
9
Invasive aspergillosis in 2002: an update.2002年侵袭性曲霉病：最新进展
Eur J Clin Microbiol Infect Dis. 2002 Mar;21(3):161-72. doi: 10.1007/s10096-002-0699-z. Epub 2002 Mar 22.
10
In vivo GM-CSF prevents dexamethasone suppression of killing of Aspergillus fumigatus conidia by bronchoalveolar macrophages.体内粒细胞-巨噬细胞集落刺激因子可防止地塞米松抑制支气管肺泡巨噬细胞对烟曲霉分生孢子的杀伤作用。
J Leukoc Biol. 2001 Dec;70(6):868-72.

鼻内给予粒细胞巨噬细胞集落刺激因子可减轻免疫抑制小鼠肺曲霉病模型中的曲霉负荷。

Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis.

作者信息

Quezada Gerardo, Koshkina Nadezhda V, Zweidler-McKay Patrick, Zhou Zichao, Kontoyiannis Dimitrios P, Kleinerman Eugenie S

机构信息

The Children's Cancer Hospital, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA.

出版信息

Antimicrob Agents Chemother. 2008 Feb;52(2):716-8. doi: 10.1128/AAC.00760-07. Epub 2007 Nov 5.

DOI:10.1128/AAC.00760-07
PMID:17984233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2224773/
Abstract

We demonstrated that intranasal granulocyte-macrophage colony-stimulating factor given to immunosuppressed mice infected with pulmonary aspergillosis resulted in a sixfold reduction in the lung fungal burden compared to the result for saline-treated mice (P = 0.045). These data suggest that lung-targeted immunotherapy may be complementary to antifungal agents and may improve patient responses.

摘要

我们证明，对于感染肺部曲霉病的免疫抑制小鼠，经鼻给予粒细胞巨噬细胞集落刺激因子后，与用生理盐水处理的小鼠相比，肺部真菌负荷降低了六倍（P = 0.045）。这些数据表明，肺部靶向免疫疗法可能是抗真菌药物的补充，并可能改善患者的反应。