Bomfim Glória, Andrade Bruno B, Santos Silvane, Clarêncio Jorge, Barral-Netto Manoel, Barral Aldina
Universidade Federal da Bahia, Salvador-Bahia, Brazil.
Am J Trop Med Hyg. 2007 Nov;77(5):854-9.
Lymphadenopathy is an early clinical sign in cutaneous leishmaniasis (CL), caused by Viannia parasites, and may help to understand the initial host response to these species of Leishmania. We report on characteristics of cells obtained from lymph nodes from cutaneous leishmaniasis patients with lymphadenopathy without ulceration (early phase, N = 21) or lymphadenopathy and ulceration (late phase, N = 29). Early-phase patients exhibited a higher proportion of neutrophils, eosinophils, and CD8+ T cells. Conversely, CD19+ B lymphocytes and plasma cells were more frequently observed in late-phase patients. The signal for IL-10 was significantly higher in late-phase patients; signals for IFN-gamma or IL-4 were similar in both groups. These data reinforce observations of an initial mixed Th1-Th2 profile as well as the early role of the CD8 T cell in cutaneous leishmaniasis. Additionally, there is a chronologic relationship between ulcer development and B-cell increase. IL-10 also increases at a late stage and may be important in limiting tissue damage.
淋巴结病是由维安尼亚属寄生虫引起的皮肤利什曼病（CL）的早期临床症状，可能有助于了解宿主对这些利什曼原虫物种的初始反应。我们报告了从无溃疡的淋巴结病（早期，N = 21）或有溃疡的淋巴结病（晚期，N = 29）的皮肤利什曼病患者的淋巴结中获得的细胞特征。早期患者表现出较高比例的中性粒细胞、嗜酸性粒细胞和CD8 + T细胞。相反，在晚期患者中更频繁地观察到CD19 + B淋巴细胞和浆细胞。晚期患者中IL - 10的信号明显更高；两组中IFN - γ或IL - 4的信号相似。这些数据强化了对初始混合Th1 - Th2谱以及CD8 T细胞在皮肤利什曼病中的早期作用的观察。此外，溃疡发展与B细胞增加之间存在时间顺序关系。IL - 10在后期也会增加，可能在限制组织损伤方面很重要。
