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关于上皮替代物Suprathel治疗热损伤手部的新策略

[New strategies for the treatment of thermally injured hands with regard to the epithelial substitute Suprathel].

作者信息

Uhlig C, Rapp M, Dittel K-K

机构信息

Klinik für Unfallchirurgie - Zentrum für Schwerbrandverletzte, Marienhospital, Stuttgart, Germany.

出版信息

Handchir Mikrochir Plast Chir. 2007 Oct;39(5):314-9. doi: 10.1055/s-2007-965234.

Abstract

The treatment of thermally injured hands has changed in the last 20 years. An early necrectomy and grafting with split-skin grafts is recommended by most burn specialists. The outcome in regard to cosmetic and functional results could be improved by early grafting. Meanwhile unnecessary grafts in burns with indeterminate depth can be avoided by new skin replacements. The new epithelial substitute Suprathel is marked by a considerable reduction of pain if it is applied on second degree burns. Therefore the mobilisation of the burned patient can be accelerated. Many hand burns were treated by Suprathel in our burn centre without severe scarring and without loss of function. We treated 76 inpatients with thermally injured hands in our burn centre from January 2004 to July 2006. Only 28 (25.7 %) of all 109 afflicted hands required a primary skin grafting. Suprathel was applied primarily in 78 hands (71.6 %). 3 hands were treated otherwise. 8 of the hands which were primarily treated by Suprathel (10.3 %) required a well-aimed grafting after one or two weeks, 70 (89.7 %) had a complete epithelisation without grafting. Many skin grafts could be avoided. We modified our strategy for the treatment of burned hands by our excellent experiences with Suprathel.

摘要

在过去20年里,手部热烧伤的治疗方法发生了变化。大多数烧伤专家建议早期进行坏死组织切除并用中厚皮片移植。早期移植可改善手部烧伤的外观和功能恢复情况。同时,通过新型皮肤替代物可以避免对深度不确定的烧伤进行不必要的移植。新型上皮替代物Suprathel应用于二度烧伤时,其显著特点是能大幅减轻疼痛。因此,可以加快烧伤患者的活动能力恢复。在我们的烧伤中心,许多手部烧伤患者使用Suprathel进行治疗,未出现严重瘢痕形成和功能丧失的情况。2004年1月至2006年7月期间,我们烧伤中心收治了76例手部热烧伤的住院患者。在所有109只受伤的手中,只有28只(25.7%)需要一期皮肤移植。78只手(71.6%)主要应用了Suprathel。另有3只手采用了其他治疗方法。最初接受Suprathel治疗的8只手(10.3%)在一两周后需要进行精准的移植,70只(89.7%)在未进行移植的情况下实现了完全上皮化。从而避免了许多皮肤移植。基于使用Suprathel取得了出色疗效,我们调整了手部烧伤的治疗策略。

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