Department of Burns and Plastic Surgery, Central Manchester University Hospital NHS Foundation Trust, Oxford Road, Manchester M13 9WL, United Kingdom.
Burns. 2013 Feb;39(1):136-41. doi: 10.1016/j.burns.2012.05.005. Epub 2012 Jun 13.
We evaluated the use of Suprathel(®), a synthetic skin substitute, for partial thickness burns in children. Thirty-three children (20 females, 13 males; mean age 29 months, range 5 months to 11 years) with burns were treated with Suprathel(®). The burns were superficial partial thickness (n=24) or mid-dermal (n=19); the median %TBSA was 4% (range 1-13%). Suprathel(®) was applied after debridement, followed by Vaseline gauze, dry gauze and crepe bandage. The outer dressings were changed every 5-10 days unless clinical problems dictated otherwise. Median healing time was 16 days (range 9-38 days). Ten patients took longer than 21 days to heal, of whom four developed hypertrophic scarring, which was strongly associated with wound infection (p<0.05). Healing time of superficial partial thickness and mid-dermal burns was not significantly different (p=0.494). Suprathel(®) is an effective skin substitute for the treatment of partial thickness burns in children. The majority of burns in children are mixed depth, and Suprathel(®) has the advantage that it may also be used to treat mid-dermal burns. It behaves like a biological dressing but is not animal derived, so is acceptable to all religious and ethnic groups. Further studies to evaluate the efficacy and cost effectiveness of Suprathel(®) compared to other dressings in children are warranted.
我们评估了合成皮肤替代物 Suprathel(®) 在儿童部分厚度烧伤中的应用。33 名(20 名女性,13 名男性;平均年龄 29 个月,范围 5 个月至 11 岁)患有烧伤的儿童接受了 Suprathel(®)治疗。烧伤为浅Ⅱ度(n=24)或深Ⅱ度(n=19);中位 TBSA 为 4%(范围 1-13%)。Suprathel(®)在清创后使用,随后使用凡士林纱布、干纱布和弹力绷带。除非临床需要,否则每 5-10 天更换一次外层敷料。中位愈合时间为 16 天(范围 9-38 天)。10 名患者的愈合时间超过 21 天,其中 4 名患者发生增生性瘢痕,这与伤口感染密切相关(p<0.05)。浅Ⅱ度和深Ⅱ度烧伤的愈合时间无显著差异(p=0.494)。Suprathel(®)是治疗儿童部分厚度烧伤的有效皮肤替代物。大多数儿童烧伤为混合深度,Suprathel(®)的优点在于它也可用于治疗深Ⅱ度烧伤。它的表现类似于生物敷料,但不是动物源性的,因此可以被所有宗教和种族接受。需要进一步研究评估 Suprathel(®)与其他敷料相比在儿童中的疗效和成本效益。