Meiler Birgit, Andrich Jürgen, Müller Thomas
Department of Neurology, St. Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany.
Mov Disord. 2008 Jan;23(1):145-6. doi: 10.1002/mds.21800.
Six patients with Parkinson's disease (PD) with severe motor complications were directly switched from their oral antiparkinsonian combination drug regime to nasoduodenal levodopa infusion without previously recommended transient treatment with levodopa alone. Duodenal levodopa infusion reduced motor complications to a considerable extent. We have shown that a prior change to an oral levodopa monotherapy and a slow titration of duodenal levodopa infusion may be skipped and a direct switch to duodenal levodopa is a safe option.
6例患有严重运动并发症的帕金森病（PD）患者，未按照先前推荐的先单独使用左旋多巴进行短暂治疗，而是直接从口服抗帕金森病联合药物治疗方案转换为经鼻十二指肠左旋多巴输注治疗。十二指肠左旋多巴输注在很大程度上减少了运动并发症。我们已经表明，口服左旋多巴单药治疗的前期转换和十二指肠左旋多巴输注的缓慢滴定步骤可以跳过，直接转换为十二指肠左旋多巴是一种安全的选择。
