Clinical Research Development Unit of Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Clinical Research Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Biomed Res Int. 2021 Oct 13;2021:8972074. doi: 10.1155/2021/8972074. eCollection 2021.
Aging is characterized by a progressive inability to maintain homeostasis, self-repair, renewal, performance, and fitness of different tissues throughout the lifespan. Senescence is occurring following enormous intracellular or extracellular stress stimuli. Cellular senescence serves as an antiproliferative process that causes permanent cell cycle arrest and restricts the lifespan. Senescent cells are characterized by terminal cell cycle arrest, enlarged lysosome, and DNA double-strand breaks as well as lipofuscin granularity, senescence-associated heterochromatin foci, and activation of DNA damage response. Curcumin, a hydrophobic polyphenol, is a bioactive chemical constituent of the rhizomes of Linn (turmeric), which has been extensively used for the alleviation of various human disorders. In addition to its pleiotropic effects, curcumin has been suggested to have antiaging features. In this review, we summarized the therapeutic potential of curcumin in the prevention and delaying of the aging process.
衰老是指随着年龄的增长，机体维持内环境稳态、自我修复、更新、发挥功能和适应能力逐渐下降的一种现象。衰老是由巨大的细胞内或细胞外应激刺激引起的。细胞衰老作为一种抗增殖过程，会导致细胞周期的永久停滞并限制寿命。衰老细胞的特征是终末细胞周期停滞、溶酶体增大、DNA 双链断裂以及脂褐素颗粒、衰老相关异染色质焦点和 DNA 损伤反应的激活。姜黄素是一种疏水性多酚，是姜黄（姜黄）根茎的生物活性化学成分，已被广泛用于缓解各种人类疾病。除了具有多种作用外，还认为姜黄素具有抗衰老作用。在这篇综述中，我们总结了姜黄素在预防和延缓衰老过程中的治疗潜力。
