Melchiors Ana Carolina, Correr Cassyano Januário, Fernández-Llimos Fernando
Universidade Federal do Paraná, Curitiba, PR, Brasil.
Arq Bras Cardiol. 2007 Oct;89(4):210-8. doi: 10.1590/s0066-782x2007001600001.
The complexity of pharmacotherapy is a result of a multiplicity of prescribed regimen factors, including the number of different drugs in the regimen, the number of dosage units per dose, the total number of prescribed doses per day and administration instructions. The Medication Regimen Complexity Index (MRCI) is a specific, reliable and valid tool used to measure the complexity of pharmacotherapy, originally developed in English language.
Transcultural translation and validation of this tool into Brazilian Portuguese.
A cross-sectional study was developed with 95 type-2 diabetes patients, receiving multiple medications. The validation process included translation into Portuguese, back-translation and pre-test of the tool, creating a new version called the Pharmacotherapy Complexity Index (PCI). The psychometric parameters were assessed, including convergent validity, discriminant validity and reliability (interclass and test-retest correlation).
The complexity of pharmacotherapy measured by the MRCI-Brazil had an average score of 15.7 points (SD=8.36). MRCI-Brazil showed significant correlation with the number of medications (r=0.86; p<0.001) and age of patients (r=0.28, p=0.005). Interrater reliability analysis found an intra-class correlation (ICC) of 0.99 (p<0.001) and test-retest correlation was of 0.997 (p<0.001).
The results have shown that the Brazilian version of the MRCI presents adequate validity and reliability, and may be useful in clinical practice and research involving the analysis of the drug regimen complexity.
药物治疗的复杂性是由多种规定治疗方案因素导致的，包括治疗方案中不同药物的数量、每剂的剂量单位数量、每日规定剂量的总数以及给药说明。药物治疗方案复杂性指数（MRCI）是一种用于衡量药物治疗复杂性的特定、可靠且有效的工具，最初以英语开发。
将该工具进行跨文化翻译并验证为巴西葡萄牙语版本。
对95名接受多种药物治疗的2型糖尿病患者开展了一项横断面研究。验证过程包括翻译成葡萄牙语、回译以及对该工具进行预测试，创建了一个名为药物治疗复杂性指数（PCI）的新版本。评估了心理测量参数，包括收敛效度、区分效度和信度（组内相关和重测相关）。
用巴西版MRCI衡量的药物治疗复杂性平均得分为15.7分（标准差=8.36）。巴西版MRCI与药物数量（r=0.86；p<0.001）和患者年龄（r=0.28，p=0.005）显示出显著相关性。评分者间信度分析发现组内相关系数（ICC）为0.99（p<0.001），重测相关系数为0.997（p<0.001）。
结果表明，巴西版MRCI具有足够的效度和信度，可能有助于涉及药物治疗方案复杂性分析的临床实践和研究。
