环磷酸腺苷对T细胞或B细胞有丝分裂原刺激淋巴细胞的差异效应。
The differential effect of cyclic AMP on lymphocyte stimulation by T- or B-cell mitogens.
作者信息
Vischer T L
出版信息
Immunology. 1976 May;30(5):735-9.
Abstract
Dibutyryl-cyclic adenosine 3'5'-monophosphate (cAMP) added to mouse spleen cell cultures under serum free conditions inhibited the stimulation of [3H]thymidine incorporation induced by T-cell mitogens much more than the one induced by B-cell mitogens. The inhibition was most impressive with phytohaemagglutinin, followed by concanavalin A, pokeweed mitogen and the specific antigen Keyhole limpet haemocyanin (KLH). The response to bacterial lipopolysaccharide (LPS) was clearly less susceptible to suppression and the effect on the stimulation induced by trypsin and suramin, both B-cell mitogens, was marginal. Similar results were obtained by addition of isoproterenol or therophyllin to the cultures.
摘要
在无血清条件下添加到小鼠脾细胞培养物中的二丁酰环腺苷酸（cAMP）对T细胞有丝分裂原诱导的[3H]胸苷掺入刺激的抑制作用远大于对B细胞有丝分裂原诱导的抑制作用。对植物血凝素的抑制作用最为显著，其次是刀豆球蛋白A、商陆有丝分裂原和特异性抗原钥孔戚血蓝蛋白（KLH）。对细菌脂多糖（LPS）的反应明显较不易受到抑制，对胰蛋白酶和苏拉明（两者均为B细胞有丝分裂原）诱导的刺激的影响很小。通过向培养物中添加异丙肾上腺素或茶碱也获得了类似的结果。
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