Szasz A, Vincze Gy
Department of Biotechnics, St. Istvan University, Budapest, Hungary.
J Cancer Res Ther. 2006 Oct-Dec;2(4):171-81. doi: 10.4103/0973-1482.29827.
We shall assume, of course, that the objective of hyperthermia is to destroy the malignant cells. Destruction definitely needs energy. Description and quality assurance of hyperthermia use the Pennes heat equation to describe the processes. However the energy balance of the Pennes-equation does not contain the hyperthermic cell-destruction energy, which is a mandatory factor of the process. We propose a generalization of the Pennes-equation, inducing the entire energy balance. The new paradigm could be a theoretical basis of the till now empirical dose-construction for oncological hyperthermia. The cell destruction is a non-equilibrium thermodynamical process, described by the equations of chemical reactions. The dynamic behavior (time dependence) has to be considered in this approach. We are going to define also a dose concept that can be objectively compared with other oncological methods. We show how such empirical dose as CEM43oC could be based theoretically as well.
当然，我们假定热疗的目标是破坏恶性细胞。破坏细胞肯定需要能量。热疗的描述和质量保证使用佩恩斯热方程来描述这些过程。然而，佩恩斯方程的能量平衡并不包含热疗破坏细胞的能量，而这是该过程的一个必要因素。我们提出对佩恩斯方程进行推广，纳入整个能量平衡。这种新的范式可能成为迄今为止肿瘤热疗经验性剂量构建的理论基础。细胞破坏是一个非平衡热力学过程，由化学反应方程描述。在这种方法中必须考虑动态行为（时间依赖性）。我们还将定义一个剂量概念，它可以与其他肿瘤学方法进行客观比较。我们还展示了诸如CEM43℃这样的经验性剂量如何也能在理论上得到依据。
