Ahmed Hussain G, Mahgoob Rayan M
Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, University of Khartoum, Sudan.
J Cancer Res Ther. 2007 Apr-Jun;3(2):127-30. doi: 10.4103/0973-1482.34696.
Oral cancer (OC) mortality is very high in Sudan, particularly among men due to the habit of Toombak use (tobacco specific nitrose amine (TSN)) rich tobacco.
Our aim was to determine whether OC is gender-specific due to increased Toombak use among males as suggested a risk for subsequent development of oral cancer.
We conducted a descriptive study of OC in Khartoum and obtained information on Toombak use, confounding variables for 39 incident patients with oral cancerous lesions and 43 hospital-based cases without apparent oral lesions.
OC was affirmed by histopathology for all patients with oral lesions, hence oral epithelial atypia and leukoplakias were detected using cytology.
Data analyzed using a computer SPSS program.
Of the 82 subjects, there were 57 (70%) Toombak users and 25 (30%) non-tobacco users. Among the 39 patients with OC, 24 (61.5%) were Toombak users and 15 (38.5%) were non-tobacco users. Among 43 with atypical changes, 10 (23.3%) were non-tobacco users and 33 (76.7%) were Toombak users. Regarding gender, only 11 (13.4%) were females, of whom 8 (72.7%) were non-tobacco users. We conclude that oral cancer, atypia and leukoplakia were high among males who were Toombak users. In view of the high incidence (29%) of OC due to Toombak use, we propose the implementation of oral screening programme restricted to Toombak users.
在苏丹，口腔癌（OC）死亡率很高，尤其是在男性中，这是由于使用富含烟草特异性亚硝胺（TSN）的图姆巴克烟草的习惯所致。
我们的目的是确定口腔癌是否因男性中使用图姆巴克烟草增加而具有性别特异性，因为这被认为是随后发生口腔癌的一个风险因素。
我们在喀土穆对口腔癌进行了一项描述性研究，并获取了39例口腔癌性病变的新发病例以及43例无明显口腔病变的医院病例的图姆巴克烟草使用情况和混杂变量信息。
所有口腔病变患者的口腔癌均通过组织病理学确诊，因此使用细胞学检测口腔上皮异型增生和白斑。
使用计算机SPSS程序分析数据。
在82名受试者中，有57名（70%）图姆巴克烟草使用者和25名（30%）非烟草使用者。在39例口腔癌患者中，24例（61.5%）是图姆巴克烟草使用者，15例（38.5%）是非烟草使用者。在43例有非典型变化的患者中，10例（23.3%）是非烟草使用者，33例（76.7%）是图姆巴克烟草使用者。关于性别，只有11名（13.4%）是女性，其中8名（72.7%）是非烟草使用者。我们得出结论，图姆巴克烟草使用者中的男性口腔癌、异型增生和白斑发病率较高。鉴于因使用图姆巴克烟草导致口腔癌的高发病率（29%），我们建议实施仅限于图姆巴克烟草使用者的口腔筛查计划。
