西尼罗河病毒抗体：一把双刃剑。

Antibodies to West Nile virus: a double-edged sword.

作者信息

Klasse Per Johan, Burton Dennis R

机构信息

Department of Microbiology and Immunology, Cornell University, Weill Medical College, 1300 York Avenue, Box 62, New York, NY 10021, USA.

出版信息

Cell Host Microbe. 2007 Apr 19;1(2):87-9. doi: 10.1016/j.chom.2007.04.001.

DOI:10.1016/j.chom.2007.04.001

PMID:18005685

Abstract

Antibodies, although critical for host defense against West Nile virus (WNV), can both neutralize and enhance viral infection. In this issue of Cell Host & Microbe, Pierson et al. dissect these opposing effects and demonstrate that, when 120 epitopes are available per WNV virion, approximately 25 are occupied by antibody at 50% neutralization. At lower occupancies, enhancement of infection dominates; at higher ones, neutralization ensues. These results are important for WNV vaccine design and for potential therapeutic use of antibodies to WNV.

摘要

抗体虽然对宿主抵御西尼罗河病毒（WNV）至关重要，但既能中和病毒感染，也能增强病毒感染。在本期《细胞宿主与微生物》杂志中，皮尔森等人剖析了这些相反的效应，并证明，当每个WNV病毒粒子有120个表位时，在50%中和率下约有25个被抗体占据。在较低占据率时，感染增强占主导；在较高占据率时，则发生中和作用。这些结果对于WNV疫苗设计以及WNV抗体的潜在治疗用途具有重要意义。