Soto Jennifer, Linsley Chase, Song Yang, Chen Binru, Fang Jun, Neyyan Josephine, Davila Raul, Lee Brandon, Wu Benjamin, Li Song
Department of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200240, China.
Nanomaterials (Basel). 2023 Aug 30;13(17):2455. doi: 10.3390/nano13172455.
Following the global spread of COVID-19, scientists and engineers have adapted technologies and developed new tools to aid in the fight against COVID-19. This review discusses various approaches to engineering biomaterials, devices, and therapeutics, especially at micro and nano levels, for the prevention, diagnosis, and treatment of infectious diseases, such as COVID-19, serving as a resource for scientists to identify specific tools that can be applicable for infectious-disease-related research, technology development, and treatment. From the design and production of equipment critical to first responders and patients using three-dimensional (3D) printing technology to point-of-care devices for rapid diagnosis, these technologies and tools have been essential to address current global needs for the prevention and detection of diseases. Moreover, advancements in organ-on-a-chip platforms provide a valuable platform to not only study infections and disease development in humans but also allow for the screening of more effective therapeutics. In addition, vaccines, the repurposing of approved drugs, biomaterials, drug delivery, and cell therapy are promising approaches for the prevention and treatment of infectious diseases. Following a comprehensive review of all these topics, we discuss unsolved problems and future directions.
在新冠病毒全球传播之后，科学家和工程师对技术进行了调整，并开发了新工具来助力抗击新冠疫情。本综述讨论了工程生物材料、设备和疗法的各种方法，尤其是在微米和纳米层面，用于预防、诊断和治疗诸如新冠病毒之类的传染病，为科学家们提供一种资源，以便他们识别可应用于传染病相关研究、技术开发和治疗的特定工具。从利用三维（3D）打印技术设计和生产急救人员及患者所需的关键设备，到用于快速诊断的即时检测设备，这些技术和工具对于满足当前全球疾病预防和检测需求至关重要。此外，芯片器官平台的进展提供了一个宝贵的平台，不仅可以研究人类感染和疾病发展情况，还能用于筛选更有效的治疗方法。此外，疫苗、已批准药物的重新利用、生物材料、药物递送和细胞疗法都是预防和治疗传染病的有前景的方法。在对所有这些主题进行全面综述之后，我们讨论了尚未解决的问题和未来方向。
