Ramírez-Osuna Moisés, Chávez Daniel, Hernández Lourdes, Molins Elias, Somanathan Ratnasamy, Aguirre Gerardo
Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, BC, México.
Molecules. 2005 Jan 31;10(1):295-301. doi: 10.3390/10010295.
Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide A (1) showed a weak activity against C. albicans and E. coli. The three non-natural analogs 2-4 proved to be inactive compounds.
本文描述了从塔斯马尼亚海洋苔藓虫Amathia wilsoni中分离出的天然生物碱阿玛酰胺A（1）的三种非溴化类似物的合成。测试了它们对枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌和白色念珠菌的抗菌活性。阿玛酰胺A（1）的测试结果显示对白色念珠菌和大肠杆菌有微弱活性。三种非天然类似物2 - 4被证明是无活性的化合物。
