稠合杂环：一些新型咪唑并[1,2-a]吡啶衍生物的合成
Fused heterocycles: synthesis of some new imidazo[1,2-a]- pyridine derivatives.
作者信息
Kasimogullari Birgul Ozden, Cesur Zafer
机构信息
Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 30416, Istanbul, Turkey.
出版信息
Molecules. 2004 Sep 30;9(10):894-901. doi: 10.3390/91000894.
Some new thiazolidines and spirothiazolidines derived from hydrazones of 2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrazide, a bioisosteric derivative of isoniazid, were synthesized and characterized by analytical, IR, (1)H- and (13)C-NMR and mass spectral data. Some of the newly synthesized compounds were screened for their antimycobacterial activities. None of the tested compounds showed significant in vitro antituberculous activity at 6.25 mirog/mL (MIC rifampin 0.031 microg/mL).
合成了一些由异烟肼的生物电子等排衍生物2-甲基咪唑并[1,2-a]吡啶-3-羧酸酰肼腙衍生而来的新型噻唑烷和螺噻唑烷，并通过分析、红外光谱、（1）H-和（13）C-核磁共振以及质谱数据对其进行了表征。对一些新合成的化合物进行了抗分枝杆菌活性筛选。在6.25微克/毫升（利福平的最低抑菌浓度为0.031微克/毫升）时，所测试的化合物均未表现出显著的体外抗结核活性。
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